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- Saints Zabulon and Susanna, of Cappadocia and Jerusalem, parents of St. Nina (Nino), enlightener of Georgia (4th century) 20 May
- Apostle Zacchaeus of the Seventy, Bishop of Caesarea in Palestine, he who was called down from the Sycamore tree by Jesus, according to the Gospel of Luke (1st century) 20 April
- Hieromartyrs Zacchaeus the Deacon and Alphaeus the Reader, at Caesarea 18 December
- Martyrs Zacchaeus the Deacon and Alphaeus the Reader, of Caesarea in Palestine (303, 304, or 307) 18 November
- New Hieromartyr Zachariah (Lobov), Archbishop of Voronezh (1937) 9 September
- New Martyr Zachariah (Zacharias) of Patras, Morea (1782) 20 January
- Martyrs Zachariah (Zacharias) the Cobbler and his wife, Mary (3rd century) 17 November
- Holy Prophet Zachariah and Righteous Elizabeth, parents of St. John the Forerunner (1st century) 5 September
- Venerable Zachariah the Recluse, of Egypt (4th century) 24 March
- Venerable Zachariah, Faster of the Kiev Caves (12th century) 24 March
- New Hieromartyr Zachariah, Metropolitan of Corinth (1684) 30 March
- Saint Zachariah, Patriarch of Jerusalem (632) 21 February
- Saint Zachariah, Pope of Rome (752) West, before the Schism 15 March
- New Hieromartyr Zachariah, Priest of Prusa (1802) 28 May
- New Hieromartyr Zachariah, priest of Prussa (1802) 22 May
- Venerable new monk-martyr Zacharias of Arta, Greece (1782) 20 June
- Hieromartyr Zacharias, Bishop of Vienne, suffered under Trajan (106) West, before the Schism 26 May
- Venerable Martyr Zacharias, by drowning in the sea 21 October
- Martyr Zacharias, in Nicomedia 10 June
- New Martyr Zafeirios of Halkidiki (c. 1821) 11 June
- Saint Zamas, first Bishop of Bologna, Italy (c. 268) West, before the Schism 24 January
- Martyrs Zebinas of Caesarea in Palestine, Germanus, Nicephorus and Antoninus (308) 20 October
- Prophet Zechariah, of the Twelve Minor Prophets (520 BC) 8 February
- Martyrs Zenaida (Zenais) and Philonilla, of Tarsus in Cilicia (1st century) 11 October
- Martyr Zenaida (Zenais) of Caesarea in Palestine, Wonderworker 7 June
- Saint Zeno (Zenon), Bishop of Maiuma (the port of Gaza) in Palestine (4th century) 26 December
- Martyrs Zeno and his servant Zenas, of Philadelphia in Arabia (Amman) (304) 22 June
- Hieromartyr Zeno of Verona, Bishop of Verona (371) West, before the Schism 12 April
- Venerable Zeno the Faster, of the Kiev Caves Monastery (14th century) 30 January
- Venerable Zeno the Hermit, of Antioch (414), disciple of St. Basil the Great 30 January
- Saint Zeno the Righteous, the Postman of Emperor Valens, hermit at Antioch (4th century) 10 February
- Martyrs Zeno, Eusebius, Neon, and Vitalis, who were converted by Apostles Jason and Sosipater (c. 63) 28 April, 29 April
- Venerable Zeno, hermit, of Egypt, wonderworker (4th century) 19 June
- New Hieromartyr Zenobius Sutormin, Priest (1920) 10 January
- Hieromartyr Zenobius, Bishop of Aegae in Cilicia, and his sister Zenobia (285) 30 October
- Saint Zenobius, first Bishop of Florence (390) West, before the Schism 25 May
- Venerable Saints Zenon and Zoilus 3 March
- Saint Zenon, Bishop of Kyrenia in Cyprus 12 June
- Martyrs Zenon, by fire, Maximus, Terentius and Pompeius, by the sword (250) 5 April
- Martyr Zenon, immersed in a cauldron of boiling lead 3 September
- Prophet Zephaniah (Sophonias) (635–605 BC) 3 December
- Saint Zephyrinus, Pope of Rome from 199 to 217, who defended Orthodox Christology against heresies West, before the Schism 26 August
- Saint Zer-Jacob, missionary of Ethiopia 26 August
- Venerable Zoe of Bethlehem, and the Virgin Photini (5th century) 13 February
- Saint Zoe of Rome (c. 286) West, before the Schism 5 July
- Martyrs Zöellus, Servilius, Felix, Silvanus, and Diocles, in Istria West, before the Schism 24 May
- Saint Zoilus and Companions, a youth martyred in Córdoba in Spain under Diocletian (c. 301) West, before the Schism 27 June
- Hieromartyr Zoilus, Priest, under Diocletian (304) 22 December
- Venerable Zosima (Verkhovsky), Elder, of Siberia (1833) 24 October
- Saints Zosima and Adrian of Volokolamsk, founders of the Sestrinsk monastery on the banks of the River Sestra (15th-16th centuries) 8 May
- Venerable Mother Zosima of Ennatsky (1935) 1 March
- New Hieromartyrs Zosima Pepenin, John Ganchev, John Rechkin, John Rodionov, Nicholas Figurov, Leonid Nikolsky, John Talızin and Alexander Orlov, Priests (1937) 20 October
- Saint Zosima, monk, of Alexandrov, Vladimir (c. 1713) 15 July
- Saint Zosimas of Cilicia, Bishop of Babylon in Egypt (6th century) 24 January, 4 June
- Venerable Zosimas of Palestine, Hieromonk (c. 560) 4 April
- Venerable Zosimas of Solovki (1478) 17 April
- Martyrs Zosimas the Hermit and Athanasius the Commentarisius (prison warden), anchorites of Cilicia (3rd–4th century) 4 January
- Martyr Zosimas the Soldier, of Apollonia, at Antioch in Pisidia (c. 89-117) 19 June
- Venerable Zosimas, ascetic of the desert 24 January
- St. Zosimas, bishop of Kumurdo (15th century) 1 May
- Saint Zosimas, Bishop of Syracuse (662) 21 January
- Venerable Zosimas, Bishop of Syracuse (662) 30 March
- Venerable Zosimas, founder and abbot of the Annunciation Monastery at Lake Vorbozoma (Vorbosomsk) (1550) 4 April
- Venerable Zosimas, founder of the Annunciation Monastery at Lake Vorbozomsk (1550) 7 November
- Martyr Zosimas, hermit of Cilicia (4th century) 19 September
- Venerable Zosimas, monk, of Phoenicia (Syria) (6th century) 8 June
- Saint Zosimus the Sinaite, of Tuman Monastery, Serbia (14th century) 8 August
- Saint Zosimus, a Greek Pope of Rome (418) West, before the Schism 26 December
- Saint Zosimus, a martyr in Spoleto in Umbria in Italy under Trajan (110) West, before the Schism 19 June
- Hieromartyr Zoticus (Zotikos) the Priest of Constantinople, Feeder and Guardian of Orphans, Cherisher of the Poor and Servant of Lepers (c. 340) 31 December
- Hieromartyr Zoticus the Priest, of Constantinople, Guardian of Orphans (c. 340) 30 December
- Hieromartyr Zoticus, Bishop of Comana in Armenia (204) 21 July
- Martyrs Zoticus, Irenaeus, Hyacinth, Amantius and Companions, at Rome (120) West, before the Schism 10 February
- Martyrs Zoticus, Rogatus, Modestus, Casutlus, between forty and fifty soldiers, in Africa West, before the Schism 12 January