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- Martyr Ia and 9,000 with her in Persia (363) 11 August, 10 September
- Virgin-martyr Ia of Cornwall (Hia, Ives), a Cornish evangelist and martyr (450) West, before the Schism 3 February
- Martyr Ia of Persia and 9,000 martyrs of Persia under Shapur II with her (362–364) 11 September
- Venerable Iakov Netsvetov of Atka Island and Ikogmute, missionary priest to the Yup’ik on the Yukon River, Enlightener of Alaska (1864) 26 July
- Venerable Iakovos Tsalikis of Euboea (Evia) the New Ascetic, Igumen of the Monastery of Saint David the Elder in Euboea (1991) 22 November
- New Martyr Iakovos, of Emesa in Syria and of Tripoli in Lebanon, ascetic (15th or 16th century) 27 June
- Venerable Iasimos the Wonderworker (Jasim), monk and healer 4 February
- Saint Ibar of Beggerin (Iberius, Ivor), an enlightener in Ireland, who mainly preached in Leinster and Meath (5th century) West, before the Schism 23 April
- Venerable Ibestion the Confessor, Egyptian ascetic (c. 450) 26 August
- Saint Ida of Herzfeld (c. 813) West, before the Schism 4 September
- Saint Iduberga (Itta), foundress of Nivelles Abbey, Belgium (652) West, before the Schism 8 May
- Saint Idus of Leinster, baptised by St Patrick, he became Bishop of Alt-Fadha in Leinster, Ireland (5th century) West, before the Schism 14 July
- Martyrs Iganatius Markov and Peter Yudin (1931) 28 May
- Venerable Ignatios of Constantinople, Patriarch of Constantinople (877-878) 23 October
- Venerable Ignatios the Sinaite, of Rethymno, Crete 29 January
- New Hieromartyr Ignatius (Bazyluk) of Jabłeczna, in Chelm and Podlasie, Poland (1942) 28 July
- Holy New Martyr Ignatius (Bazyluk), at St Onuphrios Monastery in Jabłeczna (1942) 9 August
- New Hieromartyr Ignatius (Dalanov), Hieromonk of Optina Monastery (1942) 21 August
- New Hieromartyr Ignatius (Lebedev), Schema-Archimandrite of the Vysokopetrovsky Monastery (St. Peter’s Monastery), Moscow (1938) 30 August
- Saint Ignatius Brianchaninov, Bishop of the Caucasus and Stavropol (1867) 30 April
- Saint Ignatius of Antioch, called 'the God-bearer', Bishop of Antioch (107) West, before the Schism 17 October
- New Monk-martyr Ignatius of Bulgaria and Mount Athos, at Constantinople (1814) 8 October
- Saint Ignatius of Mariupol in the Crimea, Metropolitan of Gothia and Kafa (1786) 3 February
- Venerable Ignatius of Mt. Stirion, monk 26 July
- Saint Ignatius of Rostov, Bishop and Wonderworker of Rostov (1288) 28 May
- New Hieromartyr Ignatius Sadkovsky, Bishop of Skopin (1938) 28 January
- Saint Ignatius the Wonderworker, Metropolitan of Mithymna (1566) 14 October
- Hieromartyr Ignatius Theophorus (the God-bearer), Bishop of Antioch (107) 20 December
- Venerable Ignatius, Abbot of the Monastery of the Deep Stream in Asia Minor (963–975) 27 September
- Venerable Ignatius, Archimandrite of the Kiev Caves (1435) 20 December
- Saint Ignatius, Bishop of Smolensk (1210) 29 January
- Saint Ignatius, Monk, near Blachernae 7 December
- Saint Ignatius, Monk, of Loma (Vologda) (Ignatii of Lomsk and Yaroslavsk) (1591) 28 December
- Blessed Igor (George), tonsured Gabriel, great prince of Chernigov and Kiev (1147) 19 September
- Venerable Igumen Zosima (Kartsev) of Orenburg, an ascetic of piety of the 19th–20th centuries (1920) 28 September
- New Hieromartyr Ilarion Felea, Priest, theology professor in Arad (1961) 18 September
- Saint Ildefonsus (Alphonse, Alonzo), Archbishop of Toledo from 657 (667) West, before the Schism 23 January
- Saint Illadan (Illathan, Iolladhan), Bishop of Rathlihen in Offaly in Ireland (6th century) West, before the Schism 10 June
- Saint Illidius (Allyre), Bishop of Clermont in Gaul (385) West, before the Schism 5 June
- Saint Illidius (Iflidius, Allyre), fourth Bishop of Clermont in Gaul, greatly revered by St Gregory of Tours (385) West, before the Schism 7 July
- Saint Illtyd (Illtut), abbot, of Llanilltyd Fawr, Wales (505) West, before the Schism 6 November
- Saint Illuminata, a virgin in Todi in Italy (c. 320) West, before the Schism 29 November
- Venerable Illyrius, monk of Mount Myrsinon in the Peloponnese 3 April
- Saint Imma (Immina), born in Würzburg, she became abbess of a convent in Karlburg in Germany (c. 752) West, before the Schism 25 November
- Venerable monk-martyrs in the Strofades (1530 or 1537) 29 September
- Saint Inan (Evan), a hermit in Ayrshire in Scotland, where churches are dedicated to him (9th century) West, before the Schism 18 August
- Saint Indract of Glastonbury (c. 710) West, before the Schism 5 February
- Hieromartyr Indract of Glastonbury, and his companions at Shapwick (c. 7th or 8th century) West, before the Schism 8 May
- Saint Ine of Wessex, King of Wessex, and his wife Queen Ethelburga (c. 740) West, before the Schism 8 September
- Saint Íñigo (Enneco) of Oña, Spain (1057) West, before the Schism 1 June
- Saints Injuriosus and Scholastica, a married couple in the Auvergne in France who lived in virginity and holiness (c. 550) West, before the Schism 25 May
- Martyrs Inna, Pinna, and Rimma (1st-2nd century), disciples of the Apostle Andrew in Scythia 20 January
- Saint Innocent (Borisov), Archbishop of Cherson and Taurica (1857) 25 May
- New Hieromartyr Innocent (Mazurin), Hierodeacon, of Buygorod, Volokolamsk (1938) 31 October
- Saint Innocent (Yastrebov), Archbishop of Astrakhan, Confessor (1928) 22 May
- Hieromartyrs Innocent and Sabbatius, and 30 others with them, in Sirmium of Pannonia (304) 4 July
- Venerable New Hieromartyr Innocent Beda, Archimandrite of Voronezh (Innokenty Bida of Poltava) (1927–1928) 24 December
- New Hieromartyr Innocent Kikin. Priest (1937) 13 October
- New Hieromartyr Innocent Letyaev, Archbishop of Kharkov and Akhtyra (1937) 1 December
- Saint Innocent of Kherson (1857) 13 December
- Venerable Innocent of Komel the Wonderworker, in Vologda (1521), disciple of St. Nilus of Sora 19 March
- Saint Innocent of Tortona, Bishop of Tortona and Confessor (350) West, before the Schism 17 April
- Saint Innocent, Archimandrite, of Glinsk Hermitage (1888) 17 September
- Saint Innocent, Bishop of Le Mans in France for over forty years (559) West, before the Schism 19 June
- Saint Innocent, Bishop of Penza (1819) 10 October
- Saint Innocent, first bishop of Irkutsk, Apostle to Siberia and Wonderworker (1731) 26 November
- Saint Innocent, Metropolitan of Moscow, Enlightener of Siberia and Alaska (1879) 31 March
- Saint Innocent, priest, on the Mount of Olives (4th century) 24 April
- The Innumerable Martyrs of Saragossa (304) West, before the Schism 3 November
- New Hieromartyr Ioan Pettai, Estonian Martyr Presbyter 20 January
- Saints Ioane (Maisuradze), Archimandrite (1957), and Giorgi-Ioane (Mkheidze), Schema-Archimandrite (1960), Confessors, of Georgia 8 September
- Holy and Righteous Ioane, Stepane, and Isaiah the Georgians 4 November
- New Hieromartyr Ioannicius (Lipovac), Metropolitan of Montenegro and the Littoral, executed by Communist partisans at the close of World War II (1945) 18 June
- Saint Ioannicius (Rudniev), Metropolitan of Kiev and Galich (1900) 7 June, 30 August
- Saint Ioannicius I, Metropolitan of Peć and Archbishop of Serbia 1272-1276 AD (1279) 23 May
- Saint Ioannicius II, First Serbian Patriarch, Wonderworker (1354) 3 September
- Saint Ioannicius the New, Schemamonk of Muscel, Romania (1638) 26 July
- Saint Ioannicius, Schema-Archimandrite, of Glinsk Hermitage (1914) 19 November
- Martyr Ioannis 29 July
- Venerable Ioannis the Palaiolavritis ("of the Old Lavra"), at St. Chariton's Monastery, in the Judean Desert 20 April
- New Hieromartyrs Ioasaph (Joasaph) Krymzin (Krimzin), abbot, and Peter Mamontov, hieromonk, both of the Holy Transfiguration Guslitsky Monastery, Moscow (1937) 19 November
- New Hieromartyr Ioasaph (Joasaph) Udalov, Bishop of Chistopol (1937) 19 November
- Saint Ioasaph of Moscow, Metropolitan of Moscow (1555) 27 July
- Venerable New Martyr Ioasaph, monk, of Mt. Athos, disciple of St. Niphon, Patriarch of Constantinople (1536) 26 October
- Saint Iosaph, monk, of Kubensk in Vologda (1453) 10 September
- Saint Ioseb (Jandierishvili) the Wonderworker, Catholicos of Georgia (1770) 17 October
- Martyr Iotam Zedgenidze, near Lake Paravani, Georgia (1465) 30 October
- Venerable Iraclie (Flocea) of Bessarabia, Protosyncellus, exarch of the monasteries of the Archdiocese of Chișinău (1964) 3 August
- Saint Iraida Tikhova, Confessor (1967) 25 July
- Virgin-martyr Irais (Rhais, Raissa) of Alexandria (308) 23 September
- Martyrs Irenaeus and Abundius (258) West, before the Schism 26 August
- Saint Irenaeus of Lyon, a Greek cleric noted for expanding Christian communities in France, combatting heresy and defining Orthodoxy (202) West, before the Schism 28 June
- Saint Irenaeus of Sirmium, Bishop in Pannonia (Hungary), martyred under Diocletian at Sirmium (Mitrovica) (304) West, before the Schism 25 March
- Saints Irenaeus, a deacon, and Mustiola, a noble lady, martyred in Chiusi in Tuscany in Italy under Aurelian for ministering to other martyrs and burying... (273) West, before the Schism 3 July
- Hieromartyr Irenaeus, Bishop of Lyon (202) 23 August
- Hieromartyr Irenaeus, Bishop of Sirmium in Hungary (304) 26 March, 6 April, 23 August
- Martyrs Irenaeus, Or, and Oropsus 22 August
- Martyrs Irenaeus, Pellegrinus and Irene, at Thessaloniki (284–305) 5 May
- Saint Irenarchus (Irenarch) the Recluse of Rostov (1616) 13 January
- Venerable Irenarchus, Abbot of Solovetsky Monastery (1628) 17 July
- Martyrs Irene and Sophia, by the sword 28 August
- Venerable Irene Chrysovolantou of Cappadocia, Abbess of Chrysovalantou (912) 28 July
- Virgin-martyr Irene Frolov (1931) 17 September
- Saint Irene of Athens, Byzantine empress regnant and a strong iconodule (803) 7 August, 9 August
- Saint Irene of Tomar, a nun martyred for her faith in Visigothic Portugal, honoured especially in Santarém (653) West, before the Schism 20 October
- Virgin-martyrs Irene, Agapia and Chionia of Aquileia, in Thessaloniki (304) 3 April
- Saint Irmengard (Irmgard of Chiemsee), Abbess of Buchau and then of Chiemsee in Germany (866) West, before the Schism 16 July
- Saint Irmina, sister of Saint Adela, daughter of Dagobert II (King of the Franks) (708) West, before the Schism 24 December
- Saint Irodion (Ionescu) of Lainici, Abbot of Lainici Monastery in Romania (1900) 3 May
- Martyr Isaac 9 December
- Venerable Saints Isaac (383), Dalmatius, and Faustus (5th century), ascetics of the Dalmatian Monastery at Constantinople 3 August
- New Martyrs Isaac and Joseph, at Karnu, Georgia (808) 16 September
- Martyrs Isaac and Martin, by the sword 22 September
- Venerable Isaac I (Antimonov, the "Elder"), Schema-Archimandrite of Optina Monastery (1894) 22 August
- Venerable New Hieromartyr Isaac II Bobrikov, Archimandrite of Optina Monastery (1938) 26 December
- Monk-martyr Isaac of Córdoba (851) West, before the Schism 3 June
- Saint Isaac of Spoleto (Isaac of Monteluco), a Syrian monk who fled the Monophysite persecution and founded a monastery in Monteluco near Spoleto (c. 550) West, before the Schism 11 April
- Saint Isaac the Confessor, founder of the Dalmatian Monastery at Constantinople (383) 22 March
- Venerable Isaac the Confessor, founder of the Dalmatian Monastery at Constantinople (383) 30 May
- Saint Isaac the Syrian (Isaac of Monteluco), Abbot of Spoleto, Italy (c. 550) 12 April
- Venerable Saint Isaac the Syrian, Bishop of Nineveh (7th century) 28 January
- Saint Isaac, Catholicos of Armenia (440) 20 November
- Saint Isaac, Hieromonk of Svyatogorsk Monastery (1903) 26 July
- Venerable Isaac, recluse of the Kiev Caves Monastery (c. 1090) 14 February
- Prophet Isaiah (8th century BC) 9 May
- Saint Isaiah of Mount Athos (14th century) 21 August
- Venerable Isaiah of Onogošt, ascetic monk who lived in a cave which would later become Ostrog Monastery (end of XVI - beginning of XVII) 28 April
- Saint Isaiah of Rostov, Bishop and Wonderworker (1090) 15 May
- Saint Isaiah of the Kiev Caves, Wonderworker (1115) 15 May
- Saint Isaias the Solitary, of Scetis and Palestine (491) 3 July
- Saint Isarnus of Marseilles, Abbot (1048) West, before the Schism 24 September
- Martyrs Isaurus and Aphrodisius, who suffered with St. Longinus (1st century) 16 October
- Hieromartyr Isaurus the Deacon, and Martyrs Innocent, Felix, Hermias, Basil, Peregrinus, Rufus, and Rufinus, of Apollonia in Macedonia (284) 6 July
- Hieromartyr Isaurus, deacon, and with him Martyrs Basil, Innocent, Felix, Hermias and Peregrinus, of Athens and Appolonia in Macedonia (284) 17 June
- Saint Isberga (Itisberga) of Aire, reputed sister of Charlemagne, nun at Aire (Aria) in the Artois, of which she is the patroness (c. 800) West, before the Schism 21 May
- Martyrs Ischyrion, a military officer, and five other soldiers, in Egypt (250) 1 June
- Venerable Ischyrion, Bishop in Egypt and hermit of Scete 23 November
- Saints Isidora and Neophyte 17 October
- Venerable Isidora the Fool-for-Christ, of Tabennisi, Egypt (c. 365) 1 May
- Saint Isidora the Fool-for-Christ, of Tabennisi, Egypt (c. 365) 10 May
- Saint Isidore of Alexandria (Isidore The Simple-Minded) (319-404) 10 May
- Martyr Isidore of Chios (251) 14 May
- Venerable Isidore of Pelusium (c. 436–440) 4 February
- Saint Isidore of Rostov, Fool-for-Christ and Wonderworker (1474) 14 May
- Saint Isidore of Scété (died c. 390), Egyptian priest and desert ascetic 15 January
- Saint Isidore of Seville, Bishop of Seville (636) West, before the Schism 4 April
- Martyrs Isidore, Acepsimas, and Leo, by fire 7 December
- New Hieromartyr Isidore, and his two children George and Irene, martyred under the Ottomans, newly revealed in 1953 18 October
- Hieromartyr Isidore, Bishop of Antioch, by the Arians (4th century) 2 January
- Martyrs Isidore, Elias and Paul of Cordoba, Spain, by the Moors (856) West, before the Schism 17 April, 30 April
- New Hieromartyr Isidore, Priest, and 72 companions at Yuriev (Dorpats), Estonia, slain by German Catholic Latins in (1472) 8 January
- Venerable Ismael (Isfael), a disciple of St Teilo in Wales, he was consecrated Bishop of Menevia by him (6th century) West, before the Schism 16 June
- New Hieromartyr Ismael Bazilevsky, Priest (1941) 4 November
- New Hieromartyrs Ismael Kudryavtsev, Eugene Popov, John Popov, Constantine Kolpetsky, Peter Grigoriev, Basil Maximov, Gleb Apukhtin, Basil Malinin, John... (1937) 10 September
- Saint Íte of Killeedy (Ita, Ytha, Meda), Hermitess in Ireland and foster-mother of Saint Brendan (570) West, before the Schism 15 January
- Saint Ithamar, Bishop of Rochester in England (656) West, before the Schism 10 June
- Saint Ivan I of Moscow (John I Daniilovich Kalita), Prince of Moscow from 1325 and Grand Prince of Vladimir from 1328 (1340) 31 March
- St. Iwig (Iwi, Ywi) Hierodeacon of Lindisfarne (c. 690) West, before the Schism 8 October